GLOBAL TESTS

Prothrombin Time (PT) Analysis
The foundation of our PT testing relies on Technoplastin HIS reagents. Sourced from rabbit brain thromboplastin, these reagents serve as a potent mixture of tissue factor, phospholipid, and calcium, ensuring reliable activation of the coagulation cascade.

Clinical Utility
The Prothrombin Time test is a versatile diagnostic tool used primarily for:
1. Screening for congenital or acquired deficiencies (extrinsic/common pathways).
2. Monitoring the efficacy of warfarin therapy.
3. Assisting in the diagnosis of Disseminated Intravascular Coagulation (DIC).
4. Detecting inhibitors specific to Factors II, V, VII, and X.

Reporting Methodology
To ensure consistency across different laboratories, results for Vitamin K antagonists are reported using the INR (International Normalized Ratio).
Activated Partial Thromboplastin Time (aPTT)
Our Technoclone aPTT reagents are scientifically formulated mixtures featuring precise ratios of activators and phospholipids. This diversity allows us to provide specific reagents with distinct sensitivities tailored to heparin, lupus anticoagulants, and extrinsic factors.

Clinical Utility
The aPTT test is a versatile diagnostic tool used primarily for:
1. Screening for congenital or acquired deficiencies in the intrinsic and contact pathways.
2. Monitoring the efficacy of heparin therapy.
3. Assisting in the diagnosis of Lupus Anticoagulants.
4. Aiding in the diagnosis of inhibitors to Factors VIII, IX, XI, and XII.

Measurement Principles
The aPTT measurement reflects the time required to form a fibrin clot via the intrinsic clotting pathway. Results are reported in seconds or ratio. For monitoring anticoagulant drugs, results are often expressed as a multiple of the mean normal time.
Fibrinogen
The Fibrinogen reagent of Technoclone is a modified Clauss Reagent. It features a high thrombin concentration, designed to make the test virtually insensitive to heparin and to significantly enhance clot detection.

Clinical Utility
The Fibrinogen assay is utilized for:
1. The diagnosis of Disseminated Intravascular Coagulation (DIC).
2. The diagnosis of liver failures.
3. Detecting qualitative abnormalities of fibrinogen.
4. Determining quantitative deficiency of fibrinogen.

Methodology & Results
The Technoclone Fibrinogen Reagent is a functional assay based upon the time required for fibrin clot formation. The results are expressed in g/dL and are determined by reading off a calibration curve.
Thrombin Time
The Thrombin Time reagent is a standardized thrombin time reagent produced from bovine thrombin, optimized for both normal and therapeutic (heparin and fibrinolytic) ranges.

Clinical Utility
The Thrombin Time assay is used:
1. To detect qualitatively abnormalities of fibrinogen.
2. To assess the effectiveness of fibrinolytic therapy.

Measurement & Interpretation
The Thrombin Time reflects the time taken forming a fibrin clot after the addition of thrombin. The results are reported in seconds. If a sample's clotting time is prolonged beyond the reference range, it indicates that the fibrinogen level or its activity is low. Additionally, it may indicate the presence of thrombin inhibitors, such as heparin or other direct thrombin inhibitors.

CALIBRATOR & CONTROL

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

FACTOR ASSAYS

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

ANTICOAGULANT TREATMENT

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

THROMBOPHILIA

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

THROMBOSIS

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

FIBRINOLYSIS

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

THROMBIN GENERATION

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

AUXILIARTY REAGENTS

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.

RESEARCH PRODUCTS

Calibrator and Control Series
Technoclone offers two different Calibrator and Control Series designed to meet varied laboratory needs.

The Coagulation Series includes values for screening tests, factor assays, and inhibitors. Crucially, this series covers not only Technoclone reagents but also reagent/analyzer combinations of competitor reagents. Consequently, all values are established both internally and externally.

The Technoclot Series is focused on values for classical routine and screening tests. In this series, all values are established exclusively with Technoclone reagents.
Parameter Coverage Comparison
1. Coagulation Series (Comprehensive)
This series offers the widest range of parameters, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Fibrinogen cleavage, Thrombin Time.
- Coagulation Factors: FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, FXIII.
- Contact Factors: HMWK, Prekallikrein.
- Special Assays & Inhibitors: ADAMTS13 Act, VWF, AT, C1-INH, Protein C, Protein S.

2. Technoclot Series (Routine)
This series is streamlined for essential routine testing, including:
- Screening & Routine: PT, aPTT, Fibrinogen, Thrombin Time.
- Inhibitors: AT.
Reference Plasma

The Reference Plasma serves as a fundamental calibration material. It is specifically utilized for the calibration of the assays mentioned previously in the Coagulation Series.
Special PT Calibration Set
The AK-Calibrant is a calibration set containing 4 calibration plasmas designed for PT standardization. It comprises a normal plasma and 3 native warfarin plasmas (PIVKA) of different levels for precise INR calibration.

Key Applications
This calibration set is utilized for:
- Generation of INR reference curves and direct INR determination.
- Determination of the laboratory specific ISI-values and MNPT.
- Generation of reference curves in percentage of norm.
Normal Control Plasma (NCP)

Normal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Abnormal Control Plasma (ACP)
Abnormal Control Plasma is used to determine and monitor the accuracy and precision of the functional assays.
Special PT Control Sets
The AK-Verification is a tri-level quality control set for the verification of International Normalized Ratio (INR) reporting.

Coagulation CON AK is a Control plasma for use as an accuracy control for oral anticoagulant therapy monitoring. The plasma is prepared from donors who have been on long-term anticoagulant therapy.